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Ropivacaine prompts ferroptosis to enhance the cisplatin-sensitivity of human colorectal cancer through SIRT1/Nrf2 signaling pathway

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Furthermore, SYNCRIP depletion resulted in a marked decrease in intracellular NAD + levels, a crucial cofactor required for the enzymatic activity of the NAD + -dependent deacetylase SIRT1 (Figure S4F-H) [27]

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